Cam Patterson Selected Research

Ligases (Synthetase)

1/2018	Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo.
1/2018	Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.
3/2016	Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.
9/2015	The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.
6/2014	The role of ubiquitin ligases in cardiac disease.
2/2014	Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP.
1/2014	Emerging evidence of coding mutations in the ubiquitin-proteasome system associated with cerebellar ataxias.
9/2013	Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates.
2/2012	p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
3/2011	The ubiquitin ligase MuRF1 protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun.

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Cam Patterson Research Topics

Disease

20	Cardiomegaly (Heart Hypertrophy) 01/2022 - 10/2004
18	Neoplasms (Cancer) 12/2017 - 05/2002
13	Hypertrophy 03/2016 - 10/2004
12	Atherosclerosis 12/2017 - 04/2002
10	Heart Diseases (Heart Disease) 02/2017 - 03/2006
9	Inflammation (Inflammations) 01/2017 - 01/2006
8	Heart Failure 09/2015 - 06/2003
7	Breast Neoplasms (Breast Cancer) 04/2015 - 01/2007
7	Atrophy 04/2015 - 11/2007
6	Myocardial Infarction 12/2014 - 06/2005
6	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2014 - 06/2005
6	Reperfusion Injury 09/2013 - 06/2005
4	Hypertension (High Blood Pressure) 04/2018 - 05/2009
4	Coronary Artery Disease (Coronary Atherosclerosis) 12/2017 - 04/2002
4	Ischemia 03/2011 - 06/2005
4	Alzheimer Disease (Alzheimer's Disease) 05/2009 - 06/2006
4	Parkinson Disease (Parkinson's Disease) 02/2009 - 06/2005
3	Fibrosis (Cirrhosis) 08/2018 - 12/2014
3	Cardiotoxicity 12/2017 - 02/2017
3	Muscular Dystrophies (Muscular Dystrophy) 01/2017 - 10/2011
3	Hypoxia (Hypoxemia) 07/2015 - 08/2012
3	Hemangiosarcoma (Angiosarcoma) 01/2014 - 06/2009
3	Muscular Atrophy (Muscle Atrophy) 04/2012 - 10/2004
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2012 - 09/2008
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 12/2019 - 09/2006
2	Obesity 12/2017 - 10/2017
2	Acute Lung Injury 01/2017 - 04/2015
2	Insulin Resistance 12/2016 - 07/2006
2	Lewis Lung Carcinoma 04/2016 - 01/2011
2	Hyperplasia 12/2014 - 05/2005
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2013 - 10/2011
2	Myocardial Ischemia (Ischemic Heart Diseases) 01/2012 - 12/2009
2	Peripheral Vascular Diseases (Peripheral Vascular Disease) 02/2011 - 03/2006
2	Ovarian Neoplasms (Ovarian Cancer) 01/2003 - 10/2002
1	Hyperphosphatemia 12/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2018
1	Hyperlipidemias (Hyperlipidemia) 12/2017
1	Type 2 Diabetes Mellitus (MODY) 08/2017

Drug/Important Bio-Agent (IBA)

33	Proteins (Proteins, Gene)FDA Link 12/2019 - 01/2003
23	UbiquitinIBA 01/2022 - 10/2004
18	Ligases (Synthetase)IBA 01/2018 - 10/2004
12	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2014 - 10/2006
7	CalcineurinIBA 05/2013 - 10/2004
6	Transcription Factors (Transcription Factor)IBA 01/2018 - 07/2006
5	Phosphotransferases (Kinase)IBA 12/2017 - 05/2002
5	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2017 - 03/2010
5	Peptides (Polypeptides)IBA 06/2016 - 01/2011
4	Glucose (Dextrose)FDA LinkGeneric 10/2017 - 07/2006
4	CytokinesIBA 01/2017 - 03/2011
3	AntioxidantsIBA 08/2017 - 07/2002
3	Peptide LibraryIBA 04/2016 - 01/2011
3	Oxygen (Dioxygen)IBA 07/2015 - 07/2002
3	Biological ProductsIBA 04/2015 - 04/2002
3	WD repeat containing planar cell polarity effectorIBA 01/2014 - 05/2008
3	LigandsIBA 05/2013 - 03/2006
3	CalpainIBA 01/2013 - 08/2011
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2011 - 01/2003
3	F-Box ProteinsIBA 02/2008 - 10/2004
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2008 - 10/2006
3	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2005 - 02/2002
2	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2022 - 11/2007
2	Fenofibrate (CiL)FDA LinkGeneric 08/2018 - 03/2016
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2017 - 03/2010
2	Tyrosine (L-Tyrosine)FDA Link 06/2017 - 05/2002
2	Tyrosine Kinase InhibitorsIBA 06/2017 - 05/2002
2	ErbB Receptors (EGF Receptor)IBA 06/2017 - 05/2002
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 06/2017 - 02/2011
2	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2017 - 03/2015
2	Radioisotopes (Radionuclides)IBA 04/2016 - 01/2011
2	Ventricular MyosinsIBA 03/2016 - 04/2009
2	Peptide Hydrolases (Proteases)FDA Link 03/2016 - 08/2011
2	Messenger RNA (mRNA)IBA 03/2016 - 10/2011
2	Brain Natriuretic Peptide (Natrecor)FDA Link 03/2016 - 04/2009
2	Sirolimus (Rapamycin)FDA Link 02/2015 - 07/2006
2	myocardinIBA 07/2014 - 05/2009
2	Serum Response FactorIBA 07/2014 - 03/2007
2	transcription factor NF-AT c3IBA 05/2013 - 01/2011
2	Apolipoproteins E (ApoE)IBA 09/2012 - 02/2008
2	ApolipoproteinsIBA 09/2012 - 07/2002
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2011 - 03/2005
2	Tacrolimus (Prograf)FDA LinkGeneric 01/2011 - 06/2009
2	AntibodiesIBA 01/2011 - 05/2008
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 10/2010 - 01/2007
2	Dexamethasone (Maxidex)FDA LinkGeneric 04/2009 - 11/2007
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 03/2008 - 06/2006
2	polyglutamineIBA 04/2007 - 09/2006
2	NucleotidesIBA 05/2006 - 05/2002
2	Pharmaceutical PreparationsIBA 01/2006 - 05/2002
2	EnzymesIBA 05/2005 - 07/2002
2	Oxidants (Oxidizing Agents)IBA 03/2005 - 07/2002
1	Multifunctional EnzymesIBA 12/2019
1	Phosphates (Orthophosphate)IBA 12/2018
1	CollagenIBA 01/2018
1	ChemokinesIBA 12/2017
1	Protein Kinases (Protein Kinase)IBA 12/2017
1	Sorafenib (BAY 43-9006)FDA Link 12/2017
1	LipidsIBA 10/2017

Therapy/Procedure

16	Therapeutics 06/2017 - 05/2002
2	Ligation 12/2014 - 06/2005
1	Precision Medicine 04/2018